{
  "version": "berm-combined-exposures-v1",
  "model": "BERM",
  "status": "STRUCTURAL_ONLY",
  "factors": [
    {
      "id": "contraceptive_state",
      "role": "named_drug_and_receiver_context",
      "coordinates": [
        "ingredient",
        "drug_class",
        "dose",
        "dose_units",
        "route",
        "schedule",
        "timing"
      ]
    },
    {
      "id": "material_interface",
      "role": "physical_interface_and_transfer_context",
      "coordinates": [
        "material_pair",
        "geometry",
        "humidity",
        "contact",
        "motion",
        "grounding"
      ]
    },
    {
      "id": "rf_device_protocol",
      "role": "named_physical_input_protocol",
      "coordinates": [
        "spectrum",
        "modulation",
        "timing",
        "electric_field",
        "sar"
      ]
    }
  ],
  "interactions": {
    "materialByRF": {
      "factors": [
        "material_interface",
        "rf_device_protocol"
      ],
      "independentFactor": false
    },
    "drugByRF": {
      "factors": [
        "contraceptive_state",
        "rf_device_protocol"
      ],
      "independentFactor": false
    },
    "sign": null,
    "magnitude": null
  },
  "layers": [
    {
      "id": "L0",
      "category": "lindgren_geometry",
      "status": "primary_premise",
      "formula": "g = eta + A tensor A",
      "version": "Lindgren-Kovacs-Liukkonen 2025"
    },
    {
      "id": "L1",
      "category": "lindgren_geometry",
      "status": "derived_with_explicit_BERM_scale",
      "formula": "delta_g = kappa(A0 tensor a + a tensor A0 + a tensor a)",
      "multiInput": "a = sum(a_p); cross terms require a declared temporal averaging operator"
    },
    {
      "id": "L2",
      "category": "berm_conditional_mechanism",
      "status": "open_calibration",
      "formula": "r_i(t) = Xi_i[S_i(history)](delta_g)",
      "owner": "BERM"
    },
    {
      "id": "L3_L4",
      "category": "imported_empirical_biology",
      "status": "component_evidence",
      "composition": "shared calcium/redox state -> production; binding and clearance retained separately"
    }
  ],
  "existingModules": {
    "physicalInterface": "berm.physics.static_tribo_interface.StaticTriboelectricInterface",
    "receiverState": "berm.modulome.state.CellStateVector",
    "production": "berm.modulome.steroidogenesis.SteroidogenesisObservation",
    "binding": "berm.biology.androgen_capacity.HormoneBindingState",
    "contrast": "berm.biology.cross_pathway_synthesis.additive_interaction_contrast",
    "publicEntryPoint": "berm.biology.combined_exposures_structure"
  },
  "hormoneStages": {
    "production": "output per viable cell in a named stimulation and redox context",
    "binding": "mass-action free testosterone from supplied consistent concentrations and constants",
    "clearance": "separately observed volume/time; concentration is not production",
    "sharedState": "one receiver/calcium/redox context, not a product of duplicate mechanism gains",
    "capacityPolicy": {
      "currentImplementation": "retain measurements and matched-context comparisons",
      "targetNode": "MALE_STEROIDOGENESIS",
      "existingCapacityGate": "steroidogenic_support",
      "newCapacityMultiplier": null,
      "doubleCountingRule": "When androgen-effective capacity already includes testosterone supply, steroidogenic_support stays neutral; no duplicate production multiplier.",
      "historicalForecastsChanged": false
    }
  },
  "measurementContract": {
    "quantities": {
      "potential_difference": "V",
      "electric_field": "V/m",
      "sar": "W/kg",
      "chemical_permeability": "m/s",
      "chemical_permeability_ratio": "1"
    },
    "conversionPolicy": "No automatic V-to-E, E-to-SAR or chemical-permeability-to-field conversion",
    "fieldStateRole": "optional_physical_measurement_input_only",
    "permeabilityScope": "named chemical, assay, timing and comparator; never a universal organ gain"
  },
  "contrastContract": {
    "function": "berm.biology.matched_interaction_contrast",
    "formula": "Y11 - Y10 - Y01 + Y00",
    "factorCount": 3,
    "contrastedFactors": 2,
    "match": [
      "third_factor",
      "endpoint",
      "units",
      "compartment",
      "timing",
      "matching_context_id",
      "evidence_kind"
    ],
    "interpretationKind": "descriptive_additive_mean_contrast",
    "missingMean": null,
    "synergyStatus": null,
    "statisticalSignificance": null
  },
  "claimIds": [
    "claim.synergy.state-conditioned-coexposure",
    "claim.synergy.contraceptive-receiver-state",
    "claim.synergy.material-device-transfer"
  ],
  "openCalibration": {
    "gaugePrescription": null,
    "physicalScale": null,
    "tissueKernel": null,
    "responseSign": null,
    "responseLag": null,
    "drugStateTransfer": null,
    "materialToTissueTransfer": null,
    "humanEndpointTransfer": null
  },
  "predictionPolicy": {
    "historicalForecastsChanged": false,
    "newCapacityMultiplier": null,
    "automaticGains": null,
    "fourthIndependentFactor": false
  }
}